Rat Anti-Mouse CD8a/Ly-2-LE/AF MBS673193 from MyBioSource.com

Product Specs
ItemRat Anti-Mouse CD8a/Ly-2-LE/AF
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS673193
Quantity0.5 mg
ApplicationsFlow Cytometry; Immunohistochemistry (Acetone Fixed/Frozen Sections); Immunoprecipitation
Conjugate/TagUnconjugated
FormatLow Endotoxin, Azide - Free (LE/AF)
ReactivityMouse
TargetCD8 alpha /Lyt-2
IsotypeIgG2a kappa
Clone53-6.7
HostRat
Antibody TypeSecondary
Immunogenalpha chain of the murine CD8 heterodimer, Mr 32-34 kDa
In the mouse, CD8 exists in two forms: (i) a CD8 heterodimer composed of an alpha chain (CD8 alpha /Lyt-2) and a beta chain (CD8 beta /Lyt-3); and (ii) a homodimer of two alpha chains. The heterodimer is found on the surface of essentially all thymocytes and the "suppressor/cytotoxic" subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8 alpha without CD8 beta. It has been suggested that CD8^+ beta ^- T cells mature extrathymically, while development of the CD8 alpha ^+ beta ^+ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8^+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8 alpha ^+ cells. The 53-6.7 monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2. 1-8
ClonalityMonoclonal